학력

(박사)서울대학교 약학대학 약학과

교육 및 연구경력

· 서울대학교 약학박사 (약물동태학 전공)
· 서울대학교 종합약학연구소 박사후연구원
· 종근당 종합연구소 책임연구원
· 바이오코아 선임연구원
· C&C신약연구소 책임연구원 - 일본 Chugai제약 연구소 파견연구원

연구 관심 분야

· 약물의 흡수, 분포, 대사 및 배설 (ADME) 연구
· PK/PD Modeling and Simulation 연구
· PBPK (Physiologically Based Pharmacokinetics) modeling 연구

강의 분야

· 약물동태학 (Pharmacokinetics)
· 약리학 (Pharmacology)
· 임상약학 (Clinical Pharmacology)

저서 및 주요 논문

논문
1. E.S. Son, X. Fei, J.H. Yoon, S.Y. Seo, H.J. Maeng, S.H. Jeong, Y.C. Kim. Comparison of pharmacokinetics and anti-pulmonary fibrosis-related effects of sulforaphane and sulforaphane N-acetylcysteine. Pharmaceutics 13: 958 (2021)

2. Y.H. Kim, Y.C. Kim, D.J. Jang, K.A. Min, J. Karmacharya, T.T.L. Nguyen, H.J. Maeng, K.H. Cho. Development of 20(S)-protopanaxadiol-loaded SNEDDS preconcentrate using comprehensive phase diagram for the enhanced dissolution and oral bioavailability. Pharmaceutics 12: 362 (2020)

3. Y.H. Kim, Y.C. Kim, J.Y. Kim, J. Byeon, H.J. Maeng, S.T. Kim, K.A. Min, D.J. Jang, K.H. Cho. Preparation and characterization of tenofovir disoproxil-loaded enteric microparticle. J. Nanosci. Nanotechnol. 20: 5796-5799 (2020)

4. E.J. Heo, S.Y. Park, H.I. Kim, J.H. Sung, H.J. Kwon, J.P. Jee, H.J. Maeng, K.H. Cho, S.T. Kim, Y.C. Kim, S.U. Choi, D.J. Jang. Optimization of hydroxypropyl methylcellulose and dextrin in development of dried nanosuspension for poorly water-soluble drug. J. Nanosci. Nanotechnol. 20: 5813-5818 (2020)

5. Y.C. Kim, K.A. Min, D.J. Jang, T.Y. Ahn, J.H. Min, B.E. Yu, K.H. Cho. Practical approaches on the long-acting injections. J. Pharm. Investig. 50: 147-157 (2020)

6. M.S. Choi, Y.C. Kim, H.J. Maeng. Therapeutic targets of vitamin D receptor ligands and their pharmacokinetic effects by modulation of transporters and metabolic enzymes. J. Pharm. Investig. 50: 1-16 (2020)

7. H.J. Maeng, J-H. Yoon, K-H. Chun, S.T. Kim, D-J. Jang, J-E. Park, Y.H. Kim, S-B. Kim, Y.C. Kim. Metabolic stability of D-allulose in biorelevant media and hepatocytes: comparison with fructose and erythritol. Foods 8: E448 (2019)

8. D.N.K. Trang, Y.C. Kim, S.H. Kwon, C.G. Jang, and H.J. Maeng. Determination of isoorientin levels in rat plasma by ultra-high-performance liquid chromatography coupled with diode array detector and its application to a pharmacokinetic study. Pharmacogn. Mag. 14: 81-86 (2019)

9. H.I. Kim, J.P. Jee, S.T. Kim, D. Kang, Y.C. Kim, H.C. Kim, S.Y. Park, H.M. Lee, K.H. Cho, D.Y. Kim, S.U. Choi, and D.J. Jang. Preparation and characterization of celocoxib nanosuspension using bead milling. J Nanosci Nanotechnol. 19: 1184-1187 (2019)

10. K. Ko, H.J. Kim, P.S. Ho, S.O. Lee, J.E. Lee, C.R. Min, Y.C. Kim, J.H. Yoon, E.J. Park, Y.J. Kwon, J.H. Yun, D.O. Yoon, J.S. Kim, W.S. Park, S.S. Oh, Y.M. Song, W.K. Cho, K. Morikawa, K.J. Lee, and C.H. Park. Discovery of a novel highly selective histamine H4 receptor antagonist for the treatment of atopic dermatitis. J. Med. Chem. 61: 2949-2961 (2018)

11. R.M. Kim, D.J. Jang, Y.C. Kim, J.H. Yoon, K.A. Min, H.J. Maeng, and K.H. Cho. Flurbiprofen-loaded solid SNEDDS peconcentrate for the enhanced solubility, in-vitro dissolution and bioavailability in rats. Pharmaceutics 10: pii: E247 (2018)

12. A. Balla, K.H. Cho, Y.C. Kim and H.J. Maeng. Simultaneous determination of procainamide and N-acetylprocainamide in rat plasma by ultra-high-pressure liquid chromatography coupled with a diode array detector and its application to a pharmacokinetic study in rats. Pharmaceutics 10: pii: E41 (2018)

13. M.H. Kwon, J.N. Yoon, Y.J. Baek, Y.C. Kim, Y.Y. Cho and H.E. Kang. Effects of poloxamer 407-induced hyperlipidemia on hepatic multidrug resistance protein 2 (Mrp2/Abcc2) and the pharmacokinetics of mycophenolic acid in rats. Biopharm Drug Dispos. 37:352-365 (2016)

14. B. Kim, Y.C. Kim and B. Park. Pomolic acid inhibits metastasis of HER2 overexpressing breast cancer cells through inactivation of the ERK pathway. Int J Oncol. 49:744-752 (2016)

15. J.H. Kim, Y.C. Kim and B. Park. Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors. Oncol Rep. 35:1020-1026 (2016)

16. S.Y. Han, B.H. You, Y.C. Kim, Y.W. Chin and Y.H. Choi. Dose-independent ADME properties and tentative identification of metabolites of α-mangostin from garcinia mangostana in mice by automated microsampling and UPLC-MS/MS methods. PLoS One. 10:e0131587 (2015)

17. Y.C. Kim, I.B. Kim, C.K. Noh, H.P. Quach, I.S.Yoon, E.C. Chow, M Kim, H.W. Jin, K.H. Cho, S.J. Chung, K.S. Pang and H.J. Maeng. Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat. J Pharm Sci. 103:3793-3805 (2014)

18. M.R. Choi, M.H. Kwon, Y.Y. Cho, H.D. Choi, Y.C. Kim and H.E. Kang. Pharmacokinetics of tolbutamide and its metabolite 4-hydroxy tolbutamide in poloxamer 407-induced hyperlipidemic rats. Biopharm Drug Dispos. 35:264-274 (2014)

19. H.E. Jin, I.B. Kim, Y.C. Kim, K.H. Cho and H.J. Maeng. Determination of cefadroxil in rat plasma and urine using LC-MS/MS and its application to pharmacokinetic and urinary excretion studies. J Chromatogr B Analyt Technol Biomed Life Sci. 947-948:103-110 (2014)

20. H.E. Jin, Y.C. Kim and H.J. Maeng. Liquid chromatography-tandem mass spectrometry for quantification of cefaclor in rat plasma and its application to pharmacokinetic studies. J Pharm Invest. 44:133-139 (2014)