학력

· 중앙대 약대 학사 (약사면허: 42281)
· 서울대 대학원 물리약학 석사 (1996.2)
· 서울대 대학원 물리약학 박사 (2001.2)

주요경력

· 삼양사 중앙연구소 책임연구원/수석연구원 (프로젝트 리더)
· 삼양바이오팜 의약바이오연구소 수석연구원 (팀장)
· 유영제약 중앙연구소 상무 (연구소장)
· 인제대학교 제약공학과 (2023.9~현재)

기타 및 학술관련 경력

<학회활동>
 2003-2006, 2008, 2010, 2011, 2013, 2015: 한민족과학기술자네트워크 (KOSEN) 전문가 
 2018.01~현재: 한국약제학회 학술위원회 위원
 2022.11~현재: 미국약제학회 (AAPS) 정회원
 2021: 제어방출학회 (CRS) 정회원
<정부과제 참여 경험> 
1. 보건복지부 보건의료기술 진흥사업 (2004 5~2006.3, 16.7억원, 참여연구원 실무책임자) 
2. 보건복지부 혁신형 연구중심병원사업 (2006 12~2011 11, 25.6억원, 참여연구원 실무책임자) 
3. 보건복지부 보건의료연구개발사업 (2009 12~2011 11, 8.93억원, 연구책임자) 
4. 보건복지부 혁신형제약기업 국제공동연구지원사업 (2014 10~2016 9, 16.68억원, 연구책임자) 
5. 사업자원부 산업핵심기술개발사업 (2017 3~ 2019.12, 56.3억원, 참여연구원)
<기업부설 연구소 경력>
· 삼양: 프로젝트 리더 및 연구책임자로서 총 30건의 연구과제 수행, 9건의 제품화 실적
· 유영: 총22건의 제품화 과제 관리, 품목허가 5건, 생물학적동등성 시험 통과 6건, 공장기술이관 8건, 의동/생동/임상/PV생산 8건, 신규과제 도출 6건, C&D수행 총 21건

연구 관심 분야

· 신약 Preformulation및 신제형 개량신약 제제설계 
· 난용성약물의 가용화 및 체내흡수 증진 연구 
· 초미세입자성 약물전달체 연구 
· 작용부위 표적나노전달체 연구
· 생분해성/생체적합성 고분자 약물 전달체 개발 
· 온도감응성약물 전달체연구- 하이드로젤 연구 
· 지속방출 제형 연구- 서방형마이크로입자, 서방형액상Depot연구
· DDS 개량신약 대량생산공정연구 (CMC)

강의 분야

· 물리약학
· 약제학
· 의약품 품질관리
· 약제학 실험
· 캡스톤디자인

저서 및 주요 논문

<논문목록>
1. So-Youn Ro, Hyeon-Muk Choi, Seung-Ho Choi, Sa-Won Lee, Soo-Jeong Lim, Tricaprin as a membrane permeability regulator: sustained small hydrophilic substance release from liposomes Journal of Pharmaceutical Investigation (2023) 53:539.548
2. Sang Yeob Park, Zion Kang Prakash Thapa, Yong Suk Jin, Joo Won Park, Hye Jung Lim, Jae Young Lee, Sa-Won Lee, Min-Hyo Seo, Min-Soo Kim, Seong Hoon Jeong, Development of sorafenib loaded nanoparticles to improve oral bioavailability using a quality by design approach. Int J Pharm. 20;566:229-238, 2019. 
3. Seung Hwan Lee, Jun Gi Hwang, Sang Yeob Park, Hye Jung Lim, Sa-Won Lee, Min-Hyo Seo, Jae Woo Kim, Jang Hee Hong, Single-Dose Comparative Pharmacokinetics of Two Formulations of Lenalidomide 25 mg in Healthy Subjects: A Randomized Crossover Study. Adv Ther. 35(2):210-217, 2018
4. Jin Park, Seok Soon Park, Kyoung Jin Lee, Eun Jin Ju, Seol Hwa Shin, Eun Jeong Ko, Sa-Won Lee, Min Hyo Seo, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi, Docetaxel-polymeric nanoparticle enhances radiotherapeutic efficacy in human pancreatic cancer, Transl Cancer Res 7(1):60-67, 2018
5. Si Yeol Song, Kyu-pyo Kim, Seong-Yun Jeong, Jin Park, Jaesook Park, Joohee Jung, Hye Kyung Chung, Sa-Won Lee, Min Hyo Seo, Jung-shin Lee, Kyung Hae Jung, Eun Kyung Choi, Polymeric nanoparticle-docetaxel for the teatment of advanced solid tumors: phase I clinical trial and preclinical data from an orthotopic pancreatic cancer model, Oncotarget, 7(47):77348-77357, 2016.
6. Joohee Jung, Sung-Jin Park, Hye Jyung Chung, Hye-Won Kang, Sa-Won Lee, Min-Hyo Seo, Heon Joo Park, Si Yeol Song, Seong-Yun Jeong, H Eun Kyung Choi, Polymeric nanoparticles containing taxanes enhance chemoradiotherapeutic efficacy in non-small cell lung cancer, Int. J. Radiation Oncology, 84(1):77-83. 2012.
7. Ha Na Woo, Hye Jyung Chung, Eun Jin Ju, Joohee Jung, Hye-Won Kang, Sa-Won Lee, Min-Hyo Seo, Jin Seong Lee, Jung Shin Lee, Heon Joo Park, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi, Polymeric nanoparticles containing taxanes enhance chemoradiotherapeutic efficacy in non-small cell lung cancer, Int. J. Radiation Oncology, 84(1):77-83. 2012.
8. Ha Na Woo, Hye Jyung Chung, Eun Jin Ju, Joohee Jung, Hye-Won Kang, Sa-Won Lee, Min-Hyo Seo, Jin Seong Lee, Jung Shin Lee, Heon Joo Park, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi, Preclinical evaluation of injectable sirolimus formulated with polymeric nanoparticle for cancer therapy, Int. J. Nanomedicine, 7, 1-12, 2012
9. Sa-Won Lee, Min-Hyuk Yun, Seung Wei Jeong, Chang-Hoon In, Ji-Young Kim, Min-Hyo Seo, Chaul-Min Pai, Sun-Ok Kim, Development of docetaxel-loaded intravenous formulation, Nanoxel-PM™ using polymer-based delivery system, J. Cont. Rel. 155, 262-271, 2011
10. Sa-Won Lee, Dong-Hoon Chang, Myung-Seop Shim, Bong-Oh Kim, Sun-Ok Kim, and Min-Hyo Seo, Ionically Fixed Polymeric Nanoparticles as a Novel Drug Carrier, Pharm. Res., 24(8), 1508-1516, 2007 
11. Bryan Howard, Zhoinggao Gao, Sa-Won Lee, Min-Hyo Seo, and Natalya Rapoport, Ultrasound-Enhanced Chemotherapy of Drug-Resistant Breast Cancer Tumors by Micellar-Encapsulated Paclitaxel. Am. J. Drug Deliv. 4(2); 97-104, 2006
12. Eun-Jin Lee, Sa-Won Lee, Han-Gon Choi and Chong-Kook Kim, Bioavailability of Cyclosporin A dispersed in Sodium Lauryl Sulfate-Dextrin based Solid Nanospheres, Int. J. Pharm., 218, 125-131, 2001
13. Sa-Won Lee, Moon-Hee Kim and Chong-Kook Kim, Encapsultion of ethanol by spray drying technique: Effect of sodium lauryl sulfate, Int. J. Pharm., 187, 193-198 (1999)
14. Sa-Won Lee, Han-Gon Choi, Mi-Kyung Lee, Zhong-Gao Gao, In-Sook Kim and Chong-Kook Kim, Trials of in situ-gelling and mucoadhesive acetaminophen liquid suppository in human subjects, Int. J. Pharm., 174, 201-207 (1998)
 
<학술회의 발표>
1. 이사원, Polymer-based nanomedicines for treatment of cancer, 한국약제학회 국제학술대회, The K Hotel서울 가야금홀, 2019.11.22 구두발표, 
2. 이사원, Polymeric micelle-based nanomedicines for treatment of cancer, Asia Pacific Consortium of Gene and Cell Therapy (APCGCT) 연례총회 및 학술대회, Hanyang Institute of Technology (HIT) center, 2019.11.8 구두발표
3. 이사원, Research trends in polymeric nanocarriers for drug delivery systems, 대한약학회 추계국제학술대회 물리약학분과 심포지움, Yeosu Expo Convention Center, 2019.10.15 구두발표
4. H. J. Lim, I. J. Choi, J. Y. Lee, M. H. Yun, S. W. Cho, S. W. Jeong, J. Y. Kim, S. W. Lee Development of Oral Solid Dosage Form for Sunitinib Free Base with Improved pH-Dependent Dissolution Rate and Absorption, AAPS PharmSci360, November 3–6, 2019, Henry B. Gonzalez Convention Center, San Antonio, Texas, USA
5. Jiyeong Kim, Inja Choi, Sa-Won Lee and Sukyen Ko, Development and validation of a quantitative method for fulvestrant in rat plasma by LC-MS/MS, AAPS PharmSci360, November 3–6, 2019, Henry B. Gonzalez Convention Center, San Antonio, Texas, USA
6. S. Y. Park, Z. Kang, J. W. Park, Y.S. Jin, H. J. Lim, J. Y. Lee, M. H. Yun, S. W. Cho, S. W. Jeong, J. Y. Kim, Y. J. Yoon, S. W. Lee, Fasted and Fed Bioequivalence Study of Sorafenib Tablet (SYO-1644) in Beagle Dogs, AAPS PharmSci360, November 3–6, 2019, Henry B. Gonzalez Convention Center, San Antonio, Texas, USA
7. Goo-Young Kim, Gyeong Hae Kim, Seung-Wei Jeojng, Minhyuk Yun, Sa-Won Lee, Chang-Hoon In, Geun Woo Jin, Gyu-Young Moon, Sang Woo Jo, Hyun-Jung Lee, Chemotherapy with Nanoparticles Platform Enhances Immunogenic Cell Death in Syngeneic Mice Model of Colon Cancer, AAPS PharmSci360, Nov,4-7, 2018, Washington DC, USA
8. J.Y. Lee, S.Y. Park, H.J.Lim, S.W. Lee, M.H. Yun, S.W Jeong, J.Y. Kim, Y.J.Yoon, M.H, Seo, Solid Dispersion of Sorafenib Tosylate with Enhanced Solubility and Bioavailability, AAPS PharmSci360, Nov,4-7, 2018, Washington DC, USA
9. H.J.Lim, S.Y. Park, J.Y. Lee, S.W. Lee, M.H. Yun, S.W.Cho, S.W Jeong, J.Y. Kim, Y.J.Yoon, Z. Kang, J.W. Park, Y.S. Jin, M.H, Seo, Pharmacokinetics study of sorafenib tablet (SYO1644) with improved bioavailability in Beagle dogs, AAPS PharmSci360, Nov,4-7, 2018, Washington DC, USA
10. S.Y. Park, Z. Kang, Y.S. Jin, J.W. Park, H.J. Lim, J.Y. Lee, S.W. Lee, M.H. Seo, M.S. Kim, S.H.Jeong, Optimization of Nanoparticle Processing to Improve Bioavailability Based on Quality by Design Approach, Controlled Release Society (CRS) Annual Meeting, July 22-24, 2018, New York, USA
11. Sa-Won Lee, Joong-Woong Cho, Gyeong-Hae Kim, Min-Hyuk Yun, Seung-Wei Jeong, Min-Hyo Seo, Reformulation of Temsirolimus using polymeric micelle technology to improve tolerability, Controlled Release Society (CRS) Annual Meeting, July 22-24, 2018, New York, USA
12. S.Y. Park, H.J. Lim, J.Y. Lee, S.W.Lee, M.H. Yun, S.W. Cho, S.W. Jeong, J.Y. Kim, Y.K. Yoon, Z. Kang, J.W. Park, Y.S. Jin, M.H. Seo, Dissolution rate and bioavailability enhancement of nanoparticulate sorafenib composition, 2017 AAPS Annual Meeting & Exposition, Nov. 12~15, 2017 (San Diego, USA)
13. Lee S. Hwang JG, Park SY, Lim HJ, Lee SW, Seo MH, Kim J, Hong JH, Single-Dose comparative pharmacokinetics of two formulations of lenalidomide 25 mg in healthy volunteers, 2017 AAPS Annual Meeting & Exposition, Nov. 12~15, 2017 (San Diego, USA)
14. 이사원, Polymer-based nanomedicines for treatment of cancer, 식약처 주관 나노안정성 전문가 워크숍, 2017.9.15 구두발표
15. 이사원, Development of nanomedicines for treatment of cancer using amphiphilic and biodegradable polymeric nanocarriers, 2017 화학공학회 제14회 약물전달 및 화장품 기술심포지움, 2017.10.27구두발표
16. Sa-Won Lee, Gyeong-Hae Kim, Hye-Jin Jang, Yilwoon Yi, Minhyo Seo, Development of a novel in vitro release test method for a polymeric micelle formulation for paclitaxel, Genexol-PM, Controlled Release Society (CRS) Annual Meeting, July 17-20, 2016, Seattle, Washington, USA
17. S.Y.Park, H.J. Lim, S.W. Lee, M.H. Yun, J.Y.Kim, K.J. Kyung, S.W. Jeong, M.H. Seo, Development of bioequivalent lenalidomide tablet to Revlimid® Capsule, 2016 AAPS Annual Meeting & Exposition, Nov. 11~17, 2016 (Colorado, Denver, USA)
18. 이사원, Advances on drug delivery systems for lung cancer, 2016년 대한폐암학회 표적치료연구회 춘계학술대회, 2016. 3. 26 구두발표
19. 이사원, 암치료를 위한 고분자 기반 나노의약품의 개발, 식품의약품안전평가원 의약품연구회 전문가 초청 세미나, 2016.3.28 구두발표
20. 이사원, Polymeric Nanoparticles as anticancer drug carrier, 나노기술 응용연구회 세미나 (세종대학교), 2016.2 구두발표
21. Sa-Won Lee, Hey-Won Kang, Do-Hoon Kim, Ji-Young Kim, Min-Hyuk Yoon, Chang-Hoon In, Seung-Wei Jeong, Sun-Ok Kim, Bum-Chan Min, Min-Hyo Seo, THE INFLUENCE OF BIWEEKLY REPEATED DOSE AND PREMEDICATION ON PHARMACOKINETICS OF PACLITAXEL-LOADED POLIMERIC NANOPARTICLES IN BEAGLE DOGS, 2010 AAPS Annual Meeting & Exposition, Nov. 14-18, 2010 (New Orleans, USA) 
22. Joohee Jung, Jin-Beom Bea, Ran Ji Yoo, Seong-Yun Jeong, Hye-Won Kang, Sa-Won Lee, Min-Hyo Seo, Hye Kyung Chung, Eun Kyung Choi, Improvement of anticancer effect by the combination of polymeric nanoparticle-docetaxel and irradiation 대한암학회 June 10-11, 2010, Lotte Hotel, Seoul, Korea 
23. Joohee Jung, Jin-Beom Bea, Ran Ji Yoo, Seong-Yun Jeong, Hye Kyung Chung, Hye-Won Kang, Sa-Won Lee, Min-Hyo Seo, Eun Kyung Choi, Improvement of radiotherapeutic efficacy by polymeric nanoparticle-docetaxel, Japan DDS Society, Annual Meeting, June 17-18, 2010, Osaka, Japan 
24. Ha-Na Woo, Eun Jin Ju, Seong-Yun Jeong, Sung-Jin Park, Joohee Jung, Sa-Won Lee, Hye-Won Kang, Bong-Oh Kim, Min-Hyo Seo, Eun Kyung Choi, Radiosensitization effect of polymeric nanoparticle-sirolimus on human cancer cells, Particles 2010, May 22-25, 2010, Orlando, USA 
25. Sa-Won Lee, Hey-Won Kang, Bong- Oh Kim, Min-Hyuk Yun, Seung-Wei Jeong, Sun-Ok Kim, Seong-Yun Jeong, Eun-Kyung Choi, Min-Hyo Seo, and Chaul-Min Pai, Docetaxel-loaded ionically fixed polymeric nanoparticles (SYP-0709) as a novel docetaxel formulation with improved anti-tumor efficacy, 10th US-Japan Symposium on Drug Delivery Systems, December 16-20, 2009, The Westin Maui Lahaina, Maui, Hawaii 
26. Sa-Won Lee, Hey-Won Kang, Bong- Oh Kim, Seung-Wei Jeong, Sun-Ok Kim, Sung-Jin Park, Joohee Jung, Ha-Na Woo, Seong-Yun Jeong, Eun-Kyung Choi, Min-Hyo Seo, PACLITAXEL-LOADED IONICALLY FIXED POLIMERIC NANOPARTICLES AS A NOVEL RADIOSENSITIZER, 2009 AAPS Annual Meeting & Exposition, Nov. 8-12, 2009 (Los Angeles, USA) 
27. Ha-Na Woo, Seong-Yun Jeong, Sung-Jin Park, Joohee Jung, Hye-Won Kang, Sa-Won Lee, Bong-Oh Kim, Min-Hyo Seo, Eun Kyung Choi, Radiosensitization effect of polymeric mTOR inhibitor complex on human cancer cells, 2nd Asian Congress of radiation research, May 17-20, 2009, COEX, Seoul, Korea 
28. Sung-Jin Park, Joohee Jung, Seong-Yun Jeong, Ha-Na Woo, Hye-Won Kang, Sa-Won Lee, Bong-Oh Kim, Min-Hyo Seo, Eun Kyung Choi, Radiosensitising effect of polymeric nanoparticle-paclitaxel, Controlled Release Society (CRS), Annual Meeting, July 18-22, 2009, Copenhagen, Denmark 
29. 이사원, Ionically fixed polymeric nanoparticles as novel drug carrier, 서울대종합약학연구소 심포지움 (서울대학교), 2007.12 구두발표 
30. 김선옥, 이연희, 정승의, 강송이, 최지연, 서민효, 이사원, 오헌승, Genexol-PM®, a polymeric micellar paclitaxel formulation, suppresses primary tumor growth and lung metastasis in a green fluorescent protein orthotopic model of breast and pancreatic cancer. 97th Annual Meeting & Exposition of American Association for Cancer Research (AACR), 2006. 6 (Washington DC, USA) 
31. Sa-Won Lee, Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Sun-Ok Kim, Bong-Oh Kim , Min-Hyo Seo, Hun-Seung Oh, Biodistribution and Excretion Study of [3H]Paclitaxel-Containing Polymeric Nanoparticles (3H-Azurexol™) in Tumor-Bearing Nude Mice. 33rd Annual Meeting & Exposition of the Controlled Release Society (CRS), 2006 (Vienna, Austria) 
32. 김선옥, 이연희, 정승의, 강송이, 최지연, 서민효, 이사원, 오헌승, Genexol-PM®, a polymeric micellar paclitaxel formulation, suppresses primary tumor growth and lung metastasis in a green fluorescent protein orthotopic model of breast cancer. 대한약학회 
33. Sa-Won Lee, Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Sun-Ok Kim, Bong-Oh Kim , Min-Hyo Seo, Hun-Seung Oh, Novel Polymeric Nanoparticles for Improving Therapeutic Effect of Anti-Mitotic Agents. 32nd Annual Meeting & Exposition of the Controlled Release Society (CRS), 2005 (Florida, USA) 
34. Sa-Won Lee, Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Sun-Ok Kim, Bong-Oh Kim , Min-Hyo Seo, Hun-Seung Oh, Paclitaxel-containing Polymeric Nanoparticles (Azurexol™) For Overcoming Paclitaxel-Resistant Cancer. AAPS Annual Meeting & Exposition, 2004, 11 (Baltimore, USA), AAPSPharmSci Vol. 6, No. 4, Abstract W5212 (2004)
35. Sa-Won Lee, Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Bong-Oh Kim , Hey-Jeong Yoon, Jeong-Kyung Kim, Min-Hyo Seo, Hun-Seung Oh, Ionically Fixed Polymeric Nanoparticles As A Novel Drug Carrier For Poorly Water-soluble Drugs. AAPS Annual Meeting & Exposition, 2003, 11 (Utah, USA), AAPSPharmSci Vol. 5, No. 4, Abstract W4139 (2003) 
36. Sa-Won Lee, Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Bong-Oh Kim , Min-Hyo Seo, Hun-Seung Oh, Ionically Fixed Polymeric Micelles As A Novel Drug Carrier. AAPS Annual Meeting & Exposition, 2002, 11 (Toronto, Canada), AAPSPharmSci Vol. 4, No. 4, Abstract W4202 (2002) 
37. S. Lee, M. Hyun, J. Yu, D. Jang, B. Kim, M. Seo, H. Oh, EFFECT OF D,L-POLYLACTIC ACID (D,L-PLA) ON PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOKINETICS OF PACLITAXEL-CONTAINING POLY(ETHYLENE OXIDE)-POLY(LACTIC ACID) (mPEG-PLA) POLYMERIC MICELLES, Proceedings of the 29th Annual Meeting of the Controlled Release Society, 2002. 7 (Seoul, Korea). 
38. S.-W. Lee and C.-K. Kim THERMO-REVERSIBLE MICROEMULSIONS AS TOPICAL DRUG DELIVERY SYSTEMS FOR A POORLY-WATER SOLUBLE DRUG, PROSTAGLANDIN E1, Proceedings of the 28th Annual Meeting of the Controlled Release Society, 2001. 7(San Diego, USA). 
39. Han-Gon Choi, Sa-Won Lee, Mi-Kyung Lee and Chong-Kook Kim, Trials of in situ-gelling and mucoadhesive acetaminophen liquid suppository in human subjects. AAPS Annual Meeting & Exposition, 1998, 11. 15-19. (San Francisco, California) 
40. S. Lee, K. Kim, C. Kim, Effects of sodium lauryl sulfate on the encapsulation of ethanol by spray-drying technique, Proceed Intern. Symp. Control. Rel. Bioact. Mater., 23, 359-360(1996) - Controlled Release Society, Inc., 1996. 7(Kyoto, Japan). 
41. 이사원, 최한곤, 박정일, 김종국, 홍삼엑기스를 함유한 분말주의 제조 및 평가, 고려인삼학회 춘계학술대회 및 총회, pp25-26, 한국인삼연초연구원 (대전). 
42. Sa-Won Lee, Moon-Hee Kim, Chong-Kook Kim and , Encapsulation of ethanol by spray drying technique: Effect of sodium lauryl sulfate, 대한약학회 춘계총회 및 학술대회, pp.263, 1999. 4. 22-23. 전남대학교 (광주). 
43. 이사원, 김종국, 분무건조법을 이용한 이부프로펜 분말엘릭실제의 제조에 미치는 황산라루릴 나트륨(SLS)의 영향, 제45회 대한약학회 추계학술대회, 1996. 10.25-26. (숙명여자대학교) 
44. Sa-Won Lee and Chong-Kook Kim, Effects of sodium lauryl sulfate on the encapsulation of ethanol by spray-drying technique,한국응용약물학회, 1996.4.18-19 (서울대학교 문화관) 
45. 이사원, 김종국, 분무건조법을 이용한 덱스트린 피막내 에탄올 봉입에 미치는 황산 라우릴 나트륨(SLS)의 영향 평가, 대한약학회, 1995.10.27-28 (성균관대 약대) 

<특허목록 (등록 특허)> 
국내외 총 66건 출원 특허 중 최근 3년내 등록된 특허 31건
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